The volume presents the proceedings of the first annual conference of the Centre of Excellence of the Technological District for Cultural Heritage and Activities of the Lazio Region (DTC Lazio). From their reading emerges a wide and extremely rich overview of the research, innovation and technology transfer capacities of the community of over 700 researchers that make up the Research Infrastructure of the Centre of Excellence. The papers, which were included in the order of the day's programme, touched on the themes of innovation and digitisation in museums, "Digital Storytelling" for the training of experts in cultural heritage and systems, the impact of the Territorial Observatory on sustainable development and socio-economic well-being, technologies for diagnostics, structural monitoring of historic buildings, technologies for the diagnostics of cultural heritage, restoration, and enhancement.